Synonyms:
aggravation, exacerbation
Meaning: action that makes a problem or a disease (or its symptoms) worse; "the aggravation of her condition resulted from lack of care"
Synonyms:
aggravation, irritation, provocation
Meaning: unfriendly behavior that causes anger or resentment
Synonyms:
aggravation, exasperation
Meaning: an exasperated feeling of annoyance