Synonyms:
brainsick, crazy, demented, disturbed, mad, sick, unbalanced, unhinged
Meaning: affected with madness or insanity; "a man who had gone mad"
Usage examples
Her mind is quite unhinged, you see... from sorrow.
While she sat, or rather crouched, unhinged by the interview, lunch-time came, and then the early afternoon, almost without her consciousness.
Meanwhile, crazed with terror, the unhinged Papuans beat a retreat. As for us, half laughing, we massaged and comforted poor Ned Land, who was swearing like one possessed.